The irresistible aroma of Spicy Southern Cheesy Chicken Spaghetti Casserole fills your kitchen with warmth, making your mouth water in anticipation. This creamy, cheesy casserole is layered with tender chicken, zesty spices, and a perfect balance of Southern comfort flavors. Whether for a family dinner, casual gathering, or cozy weeknight meal, this dish is guaranteed to delight.
For a sweet treat to follow, check out these caramel coconut cookies for the perfect dessert pairing.
Why You’ll Love This Recipe
- Quick and flavorful: Minimal prep time delivers maximum taste.
- Perfect for entertaining: Impress guests with a visually stunning and cheesy casserole.
- Customizable: Swap pasta shapes or protein to suit your taste.
- Comfort food at its best: Creamy, cheesy, and just the right amount of spice.
This dish has become a family favorite—every bite is comfort on a plate. My uncle even called it “the best thing since sliced bread!”
Ingredients
For the Casserole:
- 3–4 boneless, skinless chicken breasts (about 1.5 lbs)
- 8 oz spaghetti
- 2 cups shredded sharp cheddar cheese
- 1 cup fresh bell peppers, chopped (red or yellow for color)
- 1 can (10.5 oz) cream of chicken soup
- 1 tsp paprika
- ½ tsp cayenne pepper (adjust to taste)
- 1 tsp garlic powder
- ¼ cup green onions, sliced
Instructions
1. Prep the Oven and Dish
Preheat your oven to 350°F (175°C). Grease a large casserole dish with nonstick spray.
2. Cook the Chicken
In a large skillet or pot over medium heat, cook chicken breasts for 6–7 minutes per side until golden brown and fully cooked. Remove from heat and shred.
3. Cook the Pasta
Boil salted water and cook spaghetti until al dente (8–10 minutes). Drain and set aside.
4. Mix the Casserole
In a large bowl, combine shredded chicken, cooked spaghetti, cream of chicken soup, chopped bell peppers, paprika, cayenne, garlic powder, and half of the shredded cheddar. Stir until evenly coated.
5. Assemble and Bake
Transfer the mixture to the prepared casserole dish. Sprinkle remaining cheddar cheese on top. Bake for 25–30 minutes until bubbly and golden brown.
6. Garnish and Serve
Let the casserole rest for 5 minutes, then sprinkle with fresh green onions before serving.
Tips for Perfect Casserole
- Creamy texture: Mix cheese into the casserole off heat before baking to avoid separation.
- Pasta perfection: Do not overcook; al dente works best for casserole consistency.
- Adjust spice: Increase or reduce cayenne to suit your heat preference.
- Make it ahead: Assemble in advance and refrigerate; bake when ready for a stress-free meal.
Storage & Reheating
- Fridge: Store leftovers in an airtight container for up to 3 days. Reheat in the oven or microwave until heated through.
- Customization: Swap chicken for shrimp, or add extra vegetables like zucchini or mushrooms for variety.
This Spicy Southern Cheesy Chicken Spaghetti Casserole combines comfort, spice, and cheesy goodness in one unforgettable dish. Perfect for family dinners, holiday gatherings, or whenever you want a hearty, satisfying meal.
Prep Time: 15 minutes
Cook Time: 30 minutes
Total Time: 45 minutes
Servings: 8
Calories: 380 per serving