Just saying Sloppy Joe Biscuit Casserole is enough to make you feel nostalgic, isn’t it? This hearty dish combines the tangy, savory flavors of classic Sloppy Joes with the buttery goodness of fluffy biscuits, making it the ultimate comfort food. Perfect for weeknight dinners, casual family meals, or feeding a hungry crowd, this casserole is easy to make, satisfying, and ready in under an hour.

Whether you want to keep it classic or get creative with cheese, veggies, or spices, this recipe hits all the right notes. Let’s dive in!
Ingredients You’ll Need
For the casserole:
- 1 lb ground beef – juicy, savory, and full of flavor
- 3/4 cup ketchup – tangy sweetness
- 1/4 cup water – to help blend flavors
- 3 tsp brown sugar – balances the savory and tangy
- 2 tsp Worcestershire sauce – adds depth and umami
- 2 tsp mustard – a little zing
- 1 tsp garlic powder & 1 tsp onion powder – pantry staples for depth
- 1/4 tsp salt – enhances all flavors
- 12 oz store-bought biscuits, cut into quarters – for fluffy, buttery bites
- 1 cup shredded cheddar cheese – melty, gooey perfection
Optional add-ins & variations:
- Extra veggies like bell peppers, mushrooms, or spinach
- Spice it up with diced jalapeños, smoked paprika, or hot sauce
- Switch cheese varieties: mozzarella, Monterey Jack, or smoked Gouda
- Use ground turkey or chicken for a lighter version
- Swap ketchup for BBQ sauce for a smoky twist
Step-by-Step Instructions
1️⃣ Preheat and Prep
Preheat your oven to 350°F (175°C). Lightly grease a 9×13-inch baking dish with cooking spray or butter.
2️⃣ Cook the Ground Beef
In a large skillet over medium heat, cook the ground beef until browned and fully cooked, about 7–10 minutes. Drain any excess fat to keep the casserole hearty but not greasy.
3️⃣ Make the Sloppy Joe Mixture
Add ketchup, water, brown sugar, Worcestershire sauce, mustard, garlic powder, onion powder, and salt to the cooked beef. Stir to combine and simmer for 5 minutes, letting all the flavors meld into that classic tangy Sloppy Joe taste.
4️⃣ Mix in the Biscuits
Remove the skillet from heat and transfer the mixture to a medium bowl. Gently toss the biscuits quarters with the meat until evenly coated, ensuring every bite is full of saucy goodness.
5️⃣ Assemble the Casserole
Spread the biscuit and beef mixture evenly in your prepared baking dish. Sprinkle shredded cheddar cheese on top for that melty, golden finish.
6️⃣ Bake to Perfection
Bake in the preheated oven for 28–30 minutes, until the biscuits are golden and the cheese is bubbly. Check the doneness by inserting a toothpick into a biscuit; it should come out clean.
7️⃣ Rest and Serve
Let the casserole rest for 5–10 minutes before serving. This helps the flavors settle and makes it easier to serve without falling apart.
Tips & Variations
- Add Veggies: Fold in bell peppers, mushrooms, or spinach for extra nutrition.
- Spice it Up: Add jalapeños, hot sauce, or smoked paprika for a kick.
- Change the Cheese: Try mozzarella, Monterey Jack, or smoked Gouda.
- Make it Lighter: Use ground turkey or chicken instead of beef.
- BBQ Twist: Swap ketchup for BBQ sauce for a smoky version.
Serving Suggestions
- Side Salad: A crisp salad with vinaigrette balances the richness.
- Vegetables: Steamed broccoli, roasted green beans, or corn on the cob make a colorful addition.
- Tangy Sides: Pickles or coleslaw complement the rich, cheesy flavors.
Storage & Make-Ahead Tips
- Refrigerate: Store leftovers in an airtight container for up to 3 days.
- Freeze: Cool completely, wrap in foil, and freeze for up to 2 months.
- Reheat: Warm in a 350°F oven or microwave individual servings until heated through.
- Make Ahead: Assemble without baking, cover, and refrigerate for up to 24 hours. Add a few extra minutes to baking if cold from the fridge.
FAQ
Can I use homemade biscuits?
Yes! Just cut them into quarters and adjust baking time as needed.
Can I make it gluten-free?
Absolutely. Use gluten-free biscuits and check that other ingredients are certified gluten-free.
Can I freeze this casserole?
Yes! Freeze in portions or as a whole casserole for up to 2 months.
Can I use other meats?
Ground turkey, chicken, or plant-based alternatives all work well. Adjust seasoning as needed.
A Comfort Food Classic
Sloppy Joe Biscuit Casserole is the perfect blend of nostalgic flavors, cheesy goodness, and cozy comfort. Quick to make, versatile, and satisfying, it’s ideal for weeknights, family gatherings, or whenever you need a hearty, heartwarming meal.
Make it yours by adding veggies, spices, or switching up the cheese. Then sit back, serve, and enjoy a dish that’s guaranteed to bring smiles to the table.