Welcome to a recipe that takes comfort food to a whole new level. This Garlic Butter Shrimp Scampi Lasagna is where Italian tradition meets seafood indulgence—a fusion of garlicky shrimp scampi layered into a creamy, cheesy lasagna that feels both elegant and comforting.

It’s the kind of dish that fills the kitchen with rich aromas and has everyone gathered around the table before it even comes out of the oven. Whether you’re hosting a dinner party, planning a cozy date night, or simply treating your family, this recipe is guaranteed to impress.
Why You’ll Love This Recipe
✨ The Best of Both Worlds – Classic lasagna comfort paired with buttery shrimp scampi.
✨ Customizable – Easily swap proteins, veggies, or cheeses to fit your taste.
✨ Restaurant-Worthy – Looks luxurious, but it’s surprisingly simple to make.
Ingredients
For the Lasagna
- 1 box lasagna noodles
- 1 lb large shrimp, peeled & deveined
- 4 cloves garlic, minced
- ½ cup butter
- ¼ cup all-purpose flour
- 2 cups milk
- 1 cup grated Parmesan cheese
- 1 cup shredded mozzarella cheese
- ¼ cup fresh parsley, chopped
- Salt & pepper, to taste
For the Garlic Butter Sauce
- ½ cup butter
- 4 cloves garlic, minced
- ¼ cup fresh parsley, chopped
- 1 tbsp lemon juice
- Salt & pepper, to taste
Step-by-Step Instructions
- Cook the noodles
Boil lasagna noodles according to package directions. Drain and set aside. - Prepare the shrimp
In a skillet, melt butter over medium heat. Add garlic and sauté until fragrant (1–2 minutes). Add shrimp and cook until pink, about 2–3 minutes per side. Remove and set aside. - Make the sauce base
In the same skillet, melt butter for the garlic butter sauce. Add garlic and cook for 1–2 minutes. Stir in flour, cooking for 1 minute to form a roux. - Build the cream sauce
Slowly whisk in the milk until smooth. Simmer until thickened, then remove from heat. Stir in Parmesan, season with salt and pepper. - Assemble the lasagna
Preheat oven to 375°F (190°C). Spread a thin layer of sauce in a greased baking dish. Layer noodles, sauce, shrimp, and mozzarella. Repeat until all ingredients are used, finishing with sauce and cheese. - Bake
Cover with foil and bake for 25 minutes. Remove foil and bake another 10 minutes until bubbly and golden. - Serve
Rest for 5 minutes before slicing. Garnish with parsley and enjoy with garlic bread or salad.
Expert Tips
- Use no-boil noodles for convenience.
- Add a pinch of red pepper flakes for heat.
- Taste and adjust seasoning—your sauce is the backbone of flavor.
Variations & Substitutions
- Swap shrimp for chicken, crab, or scallops.
- Make it vegetarian with sautéed zucchini, mushrooms, or spinach.
- Lighten it up with low-fat milk and reduced-fat cheese.
Serving Suggestions
This lasagna shines on its own, but it’s even better with:
- A crisp green salad 🥗
- Warm garlic bread 🥖
- A chilled glass of Pinot Grigio or lemonade 🍋
FAQs
Can I make it ahead?
Yes! Assemble a day in advance and refrigerate. Just add 10–15 minutes to bake time.
Can I freeze leftovers?
Absolutely. Freeze in portions, thaw overnight, and reheat in the oven.
Can I use no-boil noodles?
Yes, but add a bit more sauce so they soften while baking.
Final Thoughts
This Garlic Butter Shrimp Scampi Lasagna is rich, creamy, and bursting with flavor—proof that comfort food can still feel gourmet. Every bite is layered with garlicky shrimp, velvety sauce, and cheesy goodness. Try it once, and it just might become your new signature dish.